Columbus Instruments Comprehensive Lab Animal Monitoring System (CLAMS)
動物呼吸代謝測試系統 

Oxymax-CLAMS-HC 小動物鼠籠式呼吸代謝測試系統
 Features / SpecificationsVO2/VCO2 and Respiratory Exchange Ratio
Animal Activity
Feeding and Drinking Monitor
Automated Food and Water Access
Core Body Temperature and Heart Rate by Telemetry
Body Mass Monitor
Wheel Running
Environmental Enclosure
Sleep Analysis
Statistical Software CLAX

Oxymax Calorimetric Assessment 卡洛里的評估方式

Columbus Instruments Oxymax system is the leading open circuit indirect calorimeter for lab animal research. Heat is derived by assessment of the exchange of oxygen for carbon dioxide that occurs during the metabolic process. The relationship between the volume of gas consumed (oxygen) and of that produced (carbon dioxide) reveals the energy content of the foodstuff utilized by the subject. This 倴alorific value is then applied to the volume of gases exchanged to compute heat.

Oxymax Sensor Technologies:

• Mass flow measurement
• Paramagnetic or Zirconia Oxide O2sensing
• Push or Pull ventilation
• Single of Multiple gas sensors

Oxymax Experiment Runtime Graph of VO2

Activity Monitoring 活動力監測
CLAMS-HC employs Columbus Instruments Opto-M4 or Opto-M5 Activity Monitor and patented (Pat: #4,337,726) process for the tabulation of activity counts associated with ambulation. The method scores counts as ambulation when the animal traverses the cage, breaking a series of IR beams in sequence. Repeated interruptions of the same IR beam do not incur ambulatory counts. All beam interruptions are scored as Total Activity. Subtraction of Ambulatory counts from the Total count provides counts associated with Stereotopy (grooming, scratching, etc.). Multiple axes serve to provide coordinate data that is employed to assess position and distance traveled.

Tecniplast model 1284 cage with X,Y &Z Axis IR Photocells

Food and Water Consumption 食物及水的攝取量監測
Bout Detection and Scoring
CLAMS-HC continuously monitors for disturbance of drinkers and feeders caused by animal contact. At the moment of disturbance detection, CLAMS-HC makes an initial, but unconfirmed, entry into a log file to identify the start of a potential feeding or drinking bout. The most recent valid mass reading from the load cell is then recorded. Some time later, the load cell will return to a stable state indicating that the animal has backed away from the drinker or feeder. The moment of restoration of stability is entered into the log file along with current mass reading. CLAMS 𨬯C then compares the difference in the two mass readings to detect liquid or food removal. An indicated loss of mass exceeding a user set threshold, typically -0.01g or -0.02g, validates the bout and the entry remains in the log file. A mass difference not meeting the threshold requirement causes the removal the entry from the log file and no bout is scored. In this manner, CLAMS-HC provides a full list of validated episodic feeding and drinking activity. During analysis, operators may group episodic bouts into meals by evaluating inter-bout periods. Inter-bout periods shorter than a user-specified time may be chained together to form a meal.

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